Publication Database

Frequencies of regulatory T cells in the peripheral blood of dogs with primary immune-mediated thrombocytopenia and chronic enteropathy:
a pilot study (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Volkmann, Maria (WE 6)

Hepworth, Matthew R (WE 6)

Ebner, Friederike (WE 6)

Rausch, Sebastian (WE 6)

Kohn, Barbara (WE 20)

Hartmann, Susanne (WE 6)

Quelle

The veterinary journal

Bandzählung: 202

Heftzählung: 3

Seiten: 630 – 633

ISSN: 1532-2971

Sprache

Englisch

Verweise

DOI: 10.1016/j.tvjl.2014.10.012

Pubmed: 25458882

Kontakt

Institut für Immunologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51834
immunologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Regulatory T (Treg) cells are specialized immune cells with a pivotal role in the maintenance of immune homeostasis and control of inflammation. However, relatively little is known about immune regulation in the peripheral blood of dogs with primary immune-mediated thrombocytopenia or chronic enteropathy. Using flow cytometry this study investigated Treg responses in the peripheral blood of dogs with respective autoimmune or chronic intestinal diseases and demonstrated that a reduction of Treg frequencies is observed in dogs with clinical signs compared to dogs undergoing remission and healthy dogs. These findings suggest that reduced frequencies of Treg cells in peripheral blood might be causally associated with the onset and/or progression of autoimmune and chronic intestinal diseases in dogs and that measurement of regulatory T cells might represent a useful tool in the monitoring of treatment response and disease progression.