Fachbereich Veterinärmedizin



    Confirmed Case of Conn‘s Syndrome in a Cat (2014)

    Dietert, K. (WE 12)
    Deutschland, M.
    Kershaw, O. (WE 12)
    Klopfleisch, R. (WE 12)
    2nd Joint European Congress of the ESVP, ESTP and ECVP. Cutting Edge Pathology
    Berlin, 27. – 30.08.2014
    Cutting Edge Pathology : 2nd Joint European Congress of the ESVP, ESTP and ECVP, 32nd Meeting of the European Society of Veterinary Pathology, 12th Meeting of the European Society of Toxicologic Pathology, 25th Meeting of the European College of Veterinar — European Society of Veterinary Pathology (Hrsg.)
    Berlin: European Society of Veterinary Pathology, 2014 — S. 114
    URL (Volltext): https://www.google.de/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0ahUKEwibjIm-0vzNAhUG7BQKHRnPDCEQFggoMAA&url=http%3A%2F%2Fwww.ecvpath.org%2Fdownload%2F438%2F&usg=AFQjCNHX_oy7n4LuxMFcDDlXcGMhry09ww&cad=rja
    Institut für Tierpathologie

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    Abstract / Zusammenfassung

    Introduction: Conn’s Syndrome (primary hyperaldosteronism) is one of the most common causes
    of hypertension in humans due to hormonal disorders. However, it is thought to be one of the rarest
    endocrine disorders in cats with only a small number of feline cases reported to date. In this
    syndrome, hyperaldosteronism results from unilateral or bilateral nodular hyperplasia, adenomas,
    adenocarcinomas or diffuse, bilateral adrenocortical hyperplasia of the zona glomerulosa.
    Materials and Methods: A 14-year old European shorthair cat with clinical hyperaldosteronaemia
    and hypokalaemia was euthanised with central nervous abnormalities, neuromuscular dysfunction
    and suspected renal failure.
    Results: Necropsy revealed concentric hypertrophy of the left ventricle, interstitial nephritis
    with marked glomerulosclerosis and multifocal intravascular thrombi within the vessels of the
    brain stem and the cerebellum. Additionally, severe myocardial and renal interstitial fibrosis was
    found and similar fibrotic changes were present in the tunica media of various blood vessels.
    The adrenal glands had multifocal, bilateral, nodular hyperplasia with intralesional, proliferating
    cells immunohistochemically positive for aldosterone.
    Conclusion: The present case indicates that Conn’s Syndrome may cause severe clinical and
    pathological changes in cats which primarily result from severe hypertension as well as regulative
    hypokalaemia. Cats with hyperaldosteronism commonly die due to renal and/or cardiac failure,
    thrombosis or musculoskeletal dysfunction so that histopathological examination with particular
    regard to the adrenal glands may support the aetiological diagnosis of Conn´s Syndrome.