Fachbereich Veterinärmedizin



    Equine procalcitonin as a potential inflammatory biomarker in horses (2014)

    Teschner, D. (WE 17)
    Barton, Ann Kristin (WE 17)
    Koopmann, C. (WE 17)
    Rieger, M.
    7th Congress of the European College of Equine Internal Medicine
    Prag, 07. – 08.11.2014
    Journal of veterinary internal medicine; 29(3) — S. 985
    ISSN: 0891-6640
    URL (Volltext): http://onlinelibrary.wiley.com/doi/10.1111/jvim.12585/pdf
    DOI: 10.1111/jvim.12585
    Klinik für Pferde, allgemeine Chirurgie und Radiologie

    Oertzenweg 19 b
    14163 Berlin
    +49 30 838 62299

    Abstract / Zusammenfassung

    In human medicine, procalcitonin (PCT) is accepted as a highly specific and early marker for microbial infections and sepsis. The aim of this study was to compare plasma PCT concentrations in horses questionable of sepsis to healthy individuals using a newly validated sandwich-ELISA for the detection of equine PCT. Plasma samples of 24 healthy horses and five horses with clinical signs of sepsis were tested. All horses were classified according to a sepsisscore adapted from Breuer et al. (2012) including data from clinical examination and laboratory data at the time of first presentation as positive for sepsis (group A, ≥ 7 score points), questionable (group B, 4–6 score points), or negative for sepsis (group C, ≤ 3 score points). The five horses with clinical signs of sepsis were assigned to group A (2 mares, 3 geldings, age: 15 4 years, bodyweight: 520 68 kg), 4 healthy horses (3 geldings and 1 mare, age: 14 5 years, bodyweight: 575 86 kg) were classified as group B and 20 healthy horses (14 geldings and 6 mares; age: 13 5 years, BDW: 529 58 kg) were classified as group C. We found a significantly higher median ePCT concentration of 8450 ng/mL in the sepsis group in contrast to 47 ng/mL for the control groups B and C (P = 0.0006). All plasma samples of the sepsis group showed increased ePCT indicating the relevance of ePCT as a valuable sepsis marker in horses.