Publication Database

Physiology: does gut hormone PYY3-36 decrease food intake in rodents? (2004)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Tschöp, M

Castañeda, T R

Joost, H G

Thöne-Reineke, C (WE 11)

Ortmann, S

Klaus, S

Hagan, M M

Chandler, P C

Oswald, K D

Benoit, S C

Seeley, R J

Kinzig, K P

Moran, T H

Beck-sickinger, A G

Koglin, N

Rodgers, R J

Blundell, J E

Ishii, Y

Beattie, A H

Holch, P

Allison, D B

Raun, K

Madsen, K

Wulff, B S

Stidsen, C E

Birringer, M

Kreuzer, O J

Schindler, M

Arndt, K

Rudolf, K

Mark, M

Deng, X Y

Whitcomb, D C

Halem, H

Taylor, J

Dong, J

Datta, R

Culler, M

Craney, S

Flora, D

Smiley, D

Heiman, M L

Withcomb, D C

Quelle

Nature : the international journal of science

Bandzählung: 430

Heftzählung: 6996

Seiten: 1 p following 165; discussion 2

ISSN: 0028-0836

Sprache

Englisch

Verweise

Pubmed: 15243972

Kontakt

Institut für Tierschutz, Tierverhalten und Versuchstierkunde

Königsweg 67
14163 Berlin
+49 30 838 61146
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.