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    Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution (2014)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    von Mentzer, Astrid
    Connor, Thomas R
    Wieler, Lothar H (WE 7)
    Semmler, Torsten (WE 7)
    Iguchi, Atsushi
    Thomson, Nicholas R
    Rasko, David A
    Joffre, Enrique
    Corander, Jukka
    Pickard, Derek
    Wiklund, Gudrun
    Svennerholm, Ann-Mari
    Sjöling, Asa
    Dougan, Gordon
    Quelle
    Nature genetics; 46 — S. 1321–1326
    ISSN: 1061-4036
    Sprache
    Englisch
    Verweise
    DOI: 10.1038/ng.3145
    Pubmed: 25383970
    Kontakt
    Institut für Mikrobiologie und Tierseuchen

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14163 Berlin
    +49 30 838 51840 / 51843
    mikrobiologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce heat-stable and/or heat-labile enterotoxins and at least 25 different colonization factors that target the intestinal mucosa. The genes encoding the enterotoxins and most of the colonization factors are located on plasmids found across diverse E. coli serogroups. Whole-genome sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally distributed lineages characterized by distinct colonization factor and enterotoxin profiles. Contrary to current notions, these relatively recently emerged lineages might harbor chromosome and plasmid combinations that optimize fitness and transmissibility. These data have implications for understanding, tracking and possibly preventing ETEC disease.