Publikationsdatenbank

Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

von Mentzer, Astrid

Connor, Thomas R

Wieler, Lothar H (WE 7)

Semmler, Torsten (WE 7)

Iguchi, Atsushi

Thomson, Nicholas R

Rasko, David A

Joffre, Enrique

Corander, Jukka

Pickard, Derek

Wiklund, Gudrun

Svennerholm, Ann-Mari

Sjöling, Asa

Dougan, Gordon

Quelle

Nature genetics

Bandzählung: 46

Seiten: 1321 – 1326

ISSN: 1061-4036

Sprache

Englisch

Verweise

DOI: 10.1038/ng.3145

Pubmed: 25383970

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce heat-stable and/or heat-labile enterotoxins and at least 25 different colonization factors that target the intestinal mucosa. The genes encoding the enterotoxins and most of the colonization factors are located on plasmids found across diverse E. coli serogroups. Whole-genome sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally distributed lineages characterized by distinct colonization factor and enterotoxin profiles. Contrary to current notions, these relatively recently emerged lineages might harbor chromosome and plasmid combinations that optimize fitness and transmissibility. These data have implications for understanding, tracking and possibly preventing ETEC disease.