Publikationsdatenbank

RNAi in Arthropods:
Insight into the Machinery and Applications for Understanding the Pathogen-Vector Interface (2012)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Barnard, Annette-Christi

Nijhof, Ard M (WE 13)

Fick, Wilma

Stutzer, Christian

Maritz-Olivier, Christine

Quelle

Genes

Bandzählung: 3

Heftzählung: 4

Seiten: 702 – 741

ISSN: 2073-4425

Sprache

Englisch

Verweise

URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000021368

DOI: 10.3390/genes3040702

Pubmed: 24705082

Kontakt

Institut für Parasitologie und Tropenveterinärmedizin

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 62310
parasitologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The availability of genome sequencing data in combination with knowledge of expressed genes via transcriptome and proteome data has greatly advanced our understanding of arthropod vectors of disease. Not only have we gained insight into vector biology, but also into their respective vector-pathogen interactions. By combining the strengths of postgenomic databases and reverse genetic approaches such as RNAi, the numbers of available drug and vaccine targets, as well as number of transgenes for subsequent transgenic or paratransgenic approaches, have expanded. These are now paving the way for in-field control strategies of vectors and their pathogens. Basic scientific questions, such as understanding the basic components of the vector RNAi machinery, is vital, as this allows for the transfer of basic RNAi machinery components into RNAi-deficient vectors, thereby expanding the genetic toolbox of these RNAi-deficient vectors and pathogens. In this review, we focus on the current knowledge of arthropod vector RNAi machinery and the impact of RNAi on understanding vector biology and vector-pathogen interactions for which vector genomic data is available on VectorBase.