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    Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE) (2014)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Zeljenková, Dagmar
    Ambrušová, Katarína
    Bartušová, Mária
    Kebis, Anton
    Kovrižnych, Jevgenij
    Krivošíková, Zora
    Kuricová, Miroslava
    Líšková, Aurélia
    Rollerová, Eva
    Spustová, Viera
    Szabová, Elena
    Tulinská, Jana
    Wimmerová, Soňa
    Levkut, Mikuláš
    Révajová, Viera
    Sevčíková, Zuzana
    Schmidt, Kerstin
    Schmidtke, Jörg
    La Paz, Jose Luis
    Corujo, Maria
    Pla, Maria
    Kleter, Gijs A
    Kok, Esther J
    Sharbati, Jutta (WE 3)
    Hanisch, Carlos (WE 3)
    Einspanier, Ralf (WE 3)
    Adel-Patient, Karine
    Wal, Jean-Michel
    Spök, Armin
    Pöting, Annette
    Kohl, Christian
    Wilhelm, Ralf
    Schiemann, Joachim
    Steinberg, Pablo
    Forschungsprojekt
    Verification of GMO risk assessment elements and review and communication of evidence collected on the biosafety of GMO (GRACE)
    Quelle
    Archives of toxicology; 88(12) — S. 2289–2314
    ISSN: 0340-5761
    Sprache
    Englisch
    Verweise
    DOI: 10.1007/s00204-014-1374-8
    Pubmed: 25270621
    Kontakt
    Institut für Veterinär-Biochemie

    Oertzenweg 19 b
    14163 Berlin
    Tel.+49 30 838 62225 Fax.+49 30 838-62584
    email:biochemie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu ) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event.