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    Filariasis asymptomatically infected donors have lower levels of disialylated IgG compared to endemic normals (2014)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    O'Regan, Noëlle Louise (WE 6)
    Steinfelder, Svenja (WE 6)
    Schwedler, Christian
    Rao, Gopala B
    Srikantam, Aparna
    Blanchard, Véronique
    Hartmann, Susanne (WE 6)
    Quelle
    Parasite Immunology; 36(12) — S. 713–720
    ISSN: 1365-3024
    Sprache
    Englisch
    Verweise
    DOI: 10.1111/pim.12137
    Pubmed: 25124516
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    14163 Berlin
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    Abstract / Zusammenfassung

    Helminths induce strong regulatory and T helper 2-type responses, whereby antibody-derived host protection and regulation are essential components. Lymphatic filariasis is an immune-mediated spectral disease that manifests in two main clinical outcomes: chronic pathology or asymptomatic infection. These outcomes depend on a multitude of factors, including parasite-induced immunoregulation and host genetic background; antibody responses contribute to this outcome. N-glycosylation of the Fc region of antibodies is a post-translational modification required for the structure and molecular function, influencing host inflammatory and regulatory responses. Altered IgG glycosylation correlates with disease, whereby decreased galactosylation is associated with inflammation while increased sialylation is associated with anti-inflammatory responses. We purified N-linked glycans from the Fc region of total IgG from Wuchereria bancrofti-infected patients characterising the two clinical manifestations (chronic pathology and asymptomatic infection) and compared them to infection-free endemic normals. Using capillary electrophoresis we found that there was no difference in galactosylation of total IgG between the three groups, however asymptomatically infected patients had significantly lower levels of disialylated IgG compared to endemic normals and patients with pathology. These data suggest that while galactosylation does not contribute to disease outcome, sialylation may be involved in asymptomatic infection. This article is protected by copyright. All rights reserved.