Publication Database

Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Chu, Van Trung

Beller, Alexander

Rausch, Sebastian (WE 6)

Strandmark, Julia

Zänker, Michael

Arbach, Olga

Kruglov, Andrey

Berek, Claudia

Quelle

Immunity

Bandzählung: 40

Heftzählung: 4

Seiten: 582 – 593

ISSN: 1074-7613

Sprache

Englisch

Verweise

DOI: 10.1016/j.immuni.2014.02.014

Pubmed: 24745334

Kontakt

Institut für Immunologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51834
immunologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Although in normal lamina propria (LP) large numbers of eosinophils are present, little is known about their role in mucosal immunity at steady state. Here we show that eosinophils are needed to maintain immune homeostasis in gut-associated tissues. By using eosinophil-deficient ΔdblGATA-1 and PHIL mice or an eosinophil-specific depletion model, we found a reduction in immunoglobulin A(+) (IgA(+)) plasma cell numbers and in secreted IgA. Eosinophil-deficient mice also showed defects in the intestinal mucous shield and alterations in microbiota composition in the gut lumen. In addition, TGF-β-dependent events including class switching to IgA in Peyer's patches (PP), the formation of CD103(+) T cells including Foxp3(+) regulatory (Treg), and also CD103(+) dendritic cells were disturbed. In vitro cultures showed that eosinophils produce factors that promote T-independent IgA class switching. Our findings show that eosinophils are important players for immune homeostasis in gut-associated tissues and add to data suggesting that eosinophils can promote tissue integrity.