Fachbereich Veterinärmedizin



    Innate immunity and inflammation of the bovine female reproductive tract in health and disease (2014)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Sheldon, I Martin
    Cronin, James G
    Healey, Gareth D
    Gabler, Christoph (WE 3)
    Heuwieser, Wolfgang (WE 19)
    Streyl, Dominik
    Bromfield, John J
    Miyamoto, Akio
    Fergani, Chrys
    Dobson, Hilary
    Untersuchungen des Einflusses von probiotischen Laktobazillen auf bovine Endometriumszellen in vitro sowie in vivo zur Behandlung der subklinischen Endometritis
    Reproduction; 148(3) — S. R41–R51
    ISSN: 1470-1626
    DOI: 10.1530/REP-14-0163
    Pubmed: 24890752
    Institut für Veterinär-Biochemie

    Oertzenweg 19 b
    14163 Berlin
    Tel.+49 30 838 62225 Fax.+49 30 838-62584

    Abstract / Zusammenfassung

    Mammalian reproductive physiology and the development of viviparity co-evolved with inflammation and immunity over millennia. Many inflammatory mediators contribute to paracrine and endocrine signalling, and the maintenance of tissue homeostasis in the female reproductive tract. However, inflammation is also a feature of microbial infections of the reproductive tract. Bacteria and viruses commonly cause endometritis, perturb ovarian follicle development and suppress the endocrine activity of the hypothalamus and pituitary in cattle. Innate immunity is an evolutionary ancient system that orchestrates host cell inflammatory responses aimed at eliminating pathogens and repairing damaged tissue. Pattern recognition receptors on host cells bind pathogen-associated molecular patterns and damage-associated molecular patterns, leading to the activation of intracellular MAPK and NFκB signalling pathways and the release of inflammatory mediators. Inflammatory mediators typically include the interleukin cytokines IL1β and IL6, chemokines such as IL8, interferons and prostaglandins. This review outlines the mechanisms of inflammation and innate immunity in the bovine female reproductive tract during health and disease condition.