Publikationsdatenbank

Innate immunity and inflammation of the bovine female reproductive tract in health and disease (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Sheldon, I Martin

Cronin, James G

Healey, Gareth D

Gabler, Christoph (WE 3)

Heuwieser, Wolfgang (WE 19)

Streyl, Dominik

Bromfield, John J

Miyamoto, Akio

Fergani, Chrys

Dobson, Hilary

Forschungsprojekt

Untersuchungen des Einflusses von probiotischen Laktobazillen auf bovine Endometriumszellen in vitro sowie in vivo zur Behandlung der subklinischen Endometritis

Quelle

Reproduction

Bandzählung: 148

Heftzählung: 3

Seiten: R41 – R51

ISSN: 1470-1626

Verweise

DOI: 10.1530/REP-14-0163

Pubmed: 24890752

Kontakt

Institut für Veterinär-Biochemie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62225
biochemie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Mammalian reproductive physiology and the development of viviparity co-evolved with inflammation and immunity over millennia. Many inflammatory mediators contribute to paracrine and endocrine signalling, and the maintenance of tissue homeostasis in the female reproductive tract. However, inflammation is also a feature of microbial infections of the reproductive tract. Bacteria and viruses commonly cause endometritis, perturb ovarian follicle development and suppress the endocrine activity of the hypothalamus and pituitary in cattle. Innate immunity is an evolutionary ancient system that orchestrates host cell inflammatory responses aimed at eliminating pathogens and repairing damaged tissue. Pattern recognition receptors on host cells bind pathogen-associated molecular patterns and damage-associated molecular patterns, leading to the activation of intracellular MAPK and NFκB signalling pathways and the release of inflammatory mediators. Inflammatory mediators typically include the interleukin cytokines IL1β and IL6, chemokines such as IL8, interferons and prostaglandins. This review outlines the mechanisms of inflammation and innate immunity in the bovine female reproductive tract during health and disease condition.