Publikationsdatenbank

Phylogenetic analysis of Staphylococcus aureus CC398 reveals a sub-lineage epidemiologically associated with infections in horses (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Abdelbary, Mohamed M H

Wittenberg, Anne

Cuny, Christiane

Layer, Franziska

Kurt, Kevin

Wieler, Lothar H (WE 7)

Walther, Birgit (WE 7)

Skov, Robert

Larsen, Jesper

Hasman, Henrik

Fitzgerald, J Ross

Smith, Tara C

Wagenaar, J A

Pantosti, Annalisa

Hallin, Marie

Struelens, Marc J

Edwards, Giles

Böse, R

Nübel, Ulrich

Witte, Wolfgang

Quelle

PLoS one; 9(2) — S. e88083

ISSN: 1932-6203

Sprache

Englisch

Verweise

URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000021361

DOI: 10.1371/journal.pone.0088083

Pubmed: 24505386

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
Gebäude 35
14163 Berlin
+49 30 838 51840 / 51843
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

In the early 2000s, a particular MRSA clonal complex (CC398) was found mainly in pigs and pig farmers in Europe. Since then, CC398 has been detected among a wide variety of animal species worldwide. We investigated the population structure of CC398 through mutation discovery at 97 genetic housekeeping loci, which are distributed along the CC398 chromosome within 195 CC398 isolates, collected from various countries and host species, including humans. Most of the isolates in this collection were received from collaborating microbiologists, who had preserved them over years. We discovered 96 bi-allelic polymorphisms, and phylogenetic analyses revealed that an epidemic sub-clone within CC398 (dubbed 'clade (C)') has spread within and between equine hospitals, where it causes nosocomial infections in horses and colonises the personnel. While clade (C) was strongly associated with S. aureus from horses in veterinary-care settings (p = 2 × 10(-7)), it remained extremely rare among S. aureus isolates from human infections.