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    Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner (2007)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Berger, J
    Voigt, J
    Seifert, F
    Ebert, B
    Macdonald, R
    Gemeinhardt, I
    Gemeinhardt, O
    Schnorr, J
    Taupitz, M
    Vater, A
    Vollmer, S
    Licha, K
    Schirner, M
    Quelle
    Proceedings / SPIE, International Society for Optical Engineering : P — S. 6631–6636
    ISSN: 0038-7355
    Verweise
    DOI: http://dx.doi.org/10.1117/12.728307
    Kontakt
    Institut für Veterinär-Anatomie

    Koserstr. 20
    14195 Berlin
    Tel.+49 30 838 53555 Fax.+49 30 838-53480
    email:anatomie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    We have developed a flying-spot scanner for fluorescence imaging of rheumatoid arthritis in the near infrared (NIR) spectral range following intravenous administration of contrast agents. The new imaging system has been characterized with respect to linearity, dynamic range and spatial resolution with the help of fluorescent phantoms. In vivo experiments were performed on an animal model of rheumatoid arthritis. Finally, NIR-fluorescence images of early stages of joint inflammation have been compared with findings from contrast enhanced MR imaging and histology.