Publikationsdatenbank

Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner (2007)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Berger, J

Voigt, J

Seifert, F

Ebert, B

Macdonald, R

Gemeinhardt, I

Gemeinhardt, O

Schnorr, J

Taupitz, M

Vater, A

Vollmer, S

Licha, K

Schirner, M

Quelle

Proceedings / SPIE, International Society for Optical Engineering : P

Seiten: 6631 – 6636

ISSN: 0038-7355

Verweise

DOI: http://dx.doi.org/10.1117/12.728307

Kontakt

Institut für Veterinär-Anatomie

Koserstr. 20
14195 Berlin
+49 30 838 75784
anatomie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

We have developed a flying-spot scanner for fluorescence imaging of rheumatoid arthritis in the near infrared (NIR) spectral range following intravenous administration of contrast agents. The new imaging system has been characterized with respect to linearity, dynamic range and spatial resolution with the help of fluorescent phantoms. In vivo experiments were performed on an animal model of rheumatoid arthritis. Finally, NIR-fluorescence images of early stages of joint inflammation have been compared with findings from contrast enhanced MR imaging and histology.