Fachbereich Veterinärmedizin



    Skin barrier disruptions in tape stripped and allergic dermatitis models have no effect on dermal penetration and systemic distribution of AHAPS-functionalized silica nanoparticles (2014)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Ostrowski, Anja (WE 12)
    Nordmeyer, Daniel
    Boreham, Alexander
    Brodwolf, Robert
    Mundhenk, Lars (WE 12)
    Fluhr, Joachim W
    Lademann, Jürgen
    Graf, Christina
    Rühl, Eckart
    Alexiev, Ulrike
    Gruber, Achim D (WE 12)
    Nanomedicine : nanotechnology, biology, and medicine; 10(7) — S. 1571–1581
    ISSN: 1549-9642
    DOI: 10.1016/j.nano.2014.04.004
    Pubmed: 24768631
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
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    Abstract / Zusammenfassung

    The skin is a potential site of entry for nanoparticles (NP) but the role of disease-associated barrier disturbances on the path and extent of skin penetration of NP remains to be characterized. Silica nanoparticles (SiO2-NP) possess promising potential for various medical applications. Here, effects of different skin barrier disruptions on the penetration of N-(6-aminohexyl)-aminopropyltrimethoxysilane (AHAPS) functionalized SiO2-NP were studied. AHAPS-SiO2-NP (55±6nm diameter) were topically applied on intact, tape stripped or on inflamed skin of SKH1 mice with induced allergic contact dermatitis for one or five consecutive days, respectively. Penetration of AHAPS-SiO2-NP through the skin was not observed regardless of the kind of barrier disruption. However, only after subcutaneous injection, AHAPS-SiO2-NP were incorporated by macrophages and transported to the regional lymph node only. Adverse effects on cells or tissues were not observed. In conclusion, AHAPS-SiO2-NP seem to not cross the normal or perturbed mouse skin.