Publikationsdatenbank

Skin barrier disruptions in tape stripped and allergic dermatitis models have no effect on dermal penetration and systemic distribution of AHAPS-functionalized silica nanoparticles (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Ostrowski, Anja (WE 12)

Nordmeyer, Daniel

Boreham, Alexander

Brodwolf, Robert

Mundhenk, Lars (WE 12)

Fluhr, Joachim W

Lademann, Jürgen

Graf, Christina

Rühl, Eckart

Alexiev, Ulrike

Gruber, Achim D (WE 12)

Quelle

Nanomedicine : nanotechnology, biology, and medicine; 10(7) — S. 1571–1581

ISSN: 1549-9642

Sprache

Englisch

Verweise

DOI: 10.1016/j.nano.2014.04.004

Pubmed: 24768631

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
Gebäude 12
14163 Berlin
+49 30 838 62450

Abstract / Zusammenfassung

The skin is a potential site of entry for nanoparticles (NP) but the role of disease-associated barrier disturbances on the path and extent of skin penetration of NP remains to be characterized. Silica nanoparticles (SiO2-NP) possess promising potential for various medical applications. Here, effects of different skin barrier disruptions on the penetration of N-(6-aminohexyl)-aminopropyltrimethoxysilane (AHAPS) functionalized SiO2-NP were studied. AHAPS-SiO2-NP (55±6nm diameter) were topically applied on intact, tape stripped or on inflamed skin of SKH1 mice with induced allergic contact dermatitis for one or five consecutive days, respectively. Penetration of AHAPS-SiO2-NP through the skin was not observed regardless of the kind of barrier disruption. However, only after subcutaneous injection, AHAPS-SiO2-NP were incorporated by macrophages and transported to the regional lymph node only. Adverse effects on cells or tissues were not observed. In conclusion, AHAPS-SiO2-NP seem to not cross the normal or perturbed mouse skin.