Publication Database

Innate immunity and inflammation of the bovine female reproductive tract in health and disease (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Sheldon, Iain Martin

Cronin, James G

Healey, Gareth D

Gabler, Christoph

Heuwieser, Wolfgang (WE 19)

Streyl, Dominik

Bromfield, John

Miyamoto, Akio

Fergani, Chrys

Dobson, Hilary

Quelle

Reproduction

Bandzählung: 148

Heftzählung: 3

Seiten: R41 – R51

ISSN: 1470-1626

Sprache

Englisch

Verweise

DOI: 10.1530/REP-14-0163

Pubmed: 24890752

Kontakt

Tierklinik für Fortpflanzung

Königsweg 65
Haus 27
14163 Berlin
+49 30 838 62618
fortpflanzungsklinik@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Mammalian reproductive physiology and the development of viviparity co-evolved with inflammation and immunity over millennia. Many inflammatory mediators contribute to paracrine and endocrine signalling, and the maintenance of tissue homeostasis in the female reproductive tract. However, inflammation is also a feature of microbial infections of the reproductive tract. Bacteria and viruses commonly cause endometritis, perturb ovarian follicle development, and suppress the endocrine activity of the hypothalamus and pituitary in cattle. Innate immunity is an evolutionary ancient system that orchestrates host cell inflammatory response aimed at eliminating pathogens and repairing damaged tissue. Pattern recognition receptors on host cells bind pathogen-associated molecular patterns and damage-associated molecular patterns, leading to activation of intracellular MAPK and NFκB signalling pathways, and the release of inflammatory mediators. Inflammatory mediators typically include the interleukin cytokines IL-1β and IL-6, chemokines such as IL-8, interferons, and prostaglandins. This review outlines the mechanisms of inflammation and innate immunity in the bovine female reproductive tract during health and disease.