Fachbereich Veterinärmedizin



    Clinical course of a malignant peripheral nerve sheath tumor in a Siberian tiger (Panthera tigris altaica) (2010)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Steinmetz, Hanspeter W
    Rütten, Maja
    Ruess-Melzer, Katja
    Ohlerth, Stefanie
    Lischer, Christoph (WE 17)
    Oevermann, Anna
    Bode-Lesniewska, Beata
    Hatt, Jean-Michel
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians; 22(6) — S. 970–975
    ISSN: 1040-6387
    Pubmed: 21088186
    Klinik für Pferde, allgemeine Chirurgie und Radiologie

    Oertzenweg 19 b
    14163 Berlin
    +49 30 838 62299

    Abstract / Zusammenfassung

    A 14-year-old male Siberian tiger (Panthera tigris altaica) was admitted with an ulcerating mass on the right thoracic wall. Radiographic and computed tomographic evaluation indicated 2 isolated cutaneous masses without any signs of metastasis. Histology of a Tru-Cut biopsy revealed an anaplastic sarcoma with giant cells. Both tumors were resected with appropriate normal tissue margins. The size of the defect did not allow primary closure of the wound; therefore, a mesh expansion technique was attempted. Three months later, the tiger had to be euthanized due to extensive metastasis to the lungs. Histomorphological features and immunohistochemical results confirmed the diagnosis of malignant peripheral nerve sheath tumor. In contrast to domestic animal experience, the tumor had spread extensively to the lungs without local reccurrence in a short period of time. Correct diagnosis requires various immunohistochemical evaluations of the tumor tissue.