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    Palmitoylation of influenza virus proteins (2013)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Veit, Michael (WE 5)
    Serebryakova, Marina V
    Kordyukova, Larisa V
    Quelle
    Biochemical Society transactions; 41(1) — S. 50–55
    ISSN: 0300-5127
    Sprache
    Englisch
    Verweise
    DOI: 10.1042/BST20120210
    Pubmed: 23356257
    Kontakt
    Institut für Virologie

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14163 Berlin
    +49 30 838 51833
    viro@zedat.fu-berlin.de

    Abstract / Zusammenfassung

    Influenza viruses contain two palmitoylated (S-acylated) proteins: the major spike protein HA (haemagglutinin) and the proton-channel M2. The present review describes the fundamental biochemistry of palmitoylation of HA: the location of palmitoylation sites and the fatty acid species bound to HA. Finally, the functional consequences of palmitoylation of HA and M2 are discussed regarding association with membrane rafts, entry of viruses into target cells by HA-mediated membrane fusion as well as the release of newly assembled virus particles from infected cells.