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    Novel small strongyle (Cyathostominae) beta-tubulin sequences (2001)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    von Samson-Himmelstjerna, G (WE 13)
    Harder, A
    Pape, M
    Schnieder, T
    Quelle
    Parasitology research; 87(2) — S. 122–125
    ISSN: 0932-0113
    Sprache
    Englisch
    Verweise
    Pubmed: 11206108
    Kontakt
    Institut für Parasitologie und Tropenveterinärmedizin

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35, 22, 23
    14163 Berlin
    Tel.+49 30 838 62310 Fax.+49 30 838 62323
    email:parasitologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Several coding sequences of the benzimidazole (BZ) target beta-tubulin have been described for different parasitic nematodes. However, until recently no tubulin sequences from Cyathostome species were available, despite the importance of BZ resistance in horses in the field. Here, we describe several full-length beta-tubulin coding sequences of two major small strongyle species, namely Cylicocyclus nassatus and Cyathostomum coronatum. In the latter sequence, the putative BZ resistant mutation in codon 200 leading to a Phe to Tyr exchange is present. High nucleotide sequence similarities (>95%) were found among the tubulin sequences of the two different genera. This will be of advantage for the development of an allele-specific BZ resistance polymerase chain reaction (PCR) for multiple small strongyle species.