Fachbereich Veterinärmedizin



    Evaluation of Rapid Immunodiagnostic Test for Rabies Diagnosis Using Clinical Brain Samples in Ethiopia (2013)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Reta, T.
    Teshale, S.
    Deresa, A.
    Ali, A.
    Getahun, G.
    Baumann, Maximillian (WE 8)
    Muller, T.
    Freuling, C. M.
    Journal of Veterinary Science and Medical Diagnosis; 2(3)
    ISSN: 2325-9590
    DOI: 10.4172/2325-9590.1000117
    Institut für Lebensmittelsicherheit und -hygiene

    Königsweg 69
    14163 Berlin
    Tel.+49 30 838 62550 Fax.+49 30 838 46029

    Abstract / Zusammenfassung

    A commercially available Rapid Immunodiagnostic Test was evaluated using 115 brain samples collected from rabies suspected dogs, cats and cattle to determine its sensitivity and specificity under field conditions in Ethiopia. The sensitivity and specificity of the Rapid Immunodiagnostic Test Kit was assessed in comparison with the Fluorescent Antibody Test (gold standard test for rabies diagnosis). Compared to the Fluorescent Antibody Test the sensitivity and specificity of the Rapid Immunodiagnostic Test was found to be 96.5% (95% CI: 90.0–99.3%) and 100% (95% CI: 88.4– 100%), respectively. It was shown that the Rapid Immunodiagnostic Test can be used in rabies surveillance programs and in targeted post-exposure prophylaxis where the standard rabies diagnostic test is not available. The improved intensity of the result in sample stored in deep freeze shows that the Rapid Immunodiagnostic Test procedures need to be standardized. The kit should be evaluated at larger scale using samples from different species of animals at the field level.