Publikationsdatenbank

Canine Cutaneous Histiocytomas are Clonal Lesions as Defined by X-linked Clonality Testing (2013)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Delcour, N M

Klopfleisch, R (WE 12)

Gruber, A D (WE 12)

Weiss, A Th A

Quelle

Journal of comparative pathology

Bandzählung: 149

Heftzählung: 2-3

Seiten: 192 – 198

ISSN: 0021-9975

Sprache

Englisch

Verweise

DOI: 10.1016/j.jcpa.2013.01.004

Pubmed: 23582639

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Canine cutaneous histiocytoma (CCH) is the most common skin tumour of young dogs. CCH is assumed to be a tumour, but as these lesions often undergo complete regression, they have also been proposed to represent hamartomas or unregulated hyperplasia of polyclonal histiocytic cells. To demonstrate a monoclonal origin of CCH, and thereby a probable neoplastic nature, a clonality assay was established based on the heterozygosity of a polymorphic microsatellite within the canine androgen receptor located on the X chromosome. Analysis of 11 histiocytomas identified a non-random X chromosome inactivation of one androgen receptor allele. CCH may, therefore, be a clonal lesion and of neoplastic nature.