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    Intestinal accumulation of urea in germ-free animals:
    a factor in caecal enlargement (1986)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Juhr, N C
    Ladeburg, M
    Quelle
    Laboratory animals; 20(3) — S. 238–241
    ISSN: 0023-6772
    Sprache
    Englisch
    Verweise
    Pubmed: 3795862
    Kontakt
    Institut für Tierschutz und Tierverhalten

    Königsweg 67
    Gebäude 21, 1. OG
    14163 Berlin
    +49 30 838 62901
    tierschutz@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    To examine the connection between caecal size and urea concentration in the caecal contents urease inhibition was tested in conventional animals and urea and urease were administered to germ-free rats and mice. Administration of alloxan and barbituric acid and immunization with urease led to slightly larger caeca in conventional animals. Neomycin treatment caused a clear enlargement of the caecum. In germ-free animals urease administration led to a reduction in the caecal size, whereas urea in the drinking water caused enlargement. The urea concentration and the urease activity in the caecal contents correlated well with the caecal weights.