Publikationsdatenbank

Intestinal accumulation of urea in germ-free animals:
a factor in caecal enlargement (1986)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Juhr, N C

Ladeburg, M

Quelle

Laboratory animals

Bandzählung: 20

Heftzählung: 3

Seiten: 238 – 241

ISSN: 0023-6772

Sprache

Englisch

Verweise

Pubmed: 3795862

Kontakt

Institut für Tierschutz, Tierverhalten und Versuchstierkunde

Königsweg 67
14163 Berlin
+49 30 838 61146
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

To examine the connection between caecal size and urea concentration in the caecal contents urease inhibition was tested in conventional animals and urea and urease were administered to germ-free rats and mice. Administration of alloxan and barbituric acid and immunization with urease led to slightly larger caeca in conventional animals. Neomycin treatment caused a clear enlargement of the caecum. In germ-free animals urease administration led to a reduction in the caecal size, whereas urea in the drinking water caused enlargement. The urea concentration and the urease activity in the caecal contents correlated well with the caecal weights.