Gebäude 21, 1. OG
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A new animal model for experimental arteriosclerosis research is studied on 20 pigs of German Landrace. 10 animals serve as control. The experiment is limited to a 6 months period.An atherogenic diet is fed after initial mechanical injury by means of a ballooncatheter. A monthly application of bovine albumin is given intravenously to produce immunological vascular damage.As a supplementary examination, a monthly analysis of blood lipids is carried out.Macroscopic examination shows arteriosclerotic lesions of the aorta and its terminal branches, the aa. coronariae and of vessels at the base of the cerebrum. The surface of the aorta covered with lesions is measured by planimetric means. The most severe lesions are seen in the aorta abdominalis, a. iliaca externa dextra and a. femoralis dextra, that are exposed in addition to mechanical trauma.Histological examination shows mainly foam cell lesions in the aorta thoracalis and the aa. coronariae. The predominant lesions of the aorta abdominalis are fibrous plaques.Analysis of blood lipids shows a significant increase of LDL-lipoprotein fraction and of cholesterol in the atherosclerotic animals.The results of this study confirm he advantages of swine as an experimental animal for arteriosclerosis research. The animal model offers the advantage of inducing in a defined period of time arteriosclerotic lesions that closely resemble human arteriosclerotic lesions with respect to their topographie distribution and morphology.