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    Effects of repeated blood samplings on locomotor activity, evasion and wheel-running activity in mice (1988)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autor
    Pfeil, Rudolf
    Quelle
    Laboratory animals; 22(1) — S. 46–50
    ISSN: 0023-6772
    Sprache
    Englisch
    Verweise
    Pubmed: 3352220
    Kontakt
    Institut für Tierschutz und Tierverhalten

    Königsweg 67
    Gebäude 21, 1. OG
    14163 Berlin
    +49 30 838 62901
    tierschutz@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    The effects of serial blood sampling on nocturnal locomotor activity, evasion, wheel-running activity and body mass were studied in male NMRI mice aged 7-8 weeks. The erythrocyte count, haematocrit and haemoglobin concentration at the beginning and end of the study showed no difference in group 1 (two samples per week, 0.08 ml each) while there was a significant decrease in the group 2 values (three samples per week, 0.08 ml each). The total amount of nocturnal locomotor activity decreased in the animals bled repeatedly while the periods with locomotor activity increased. These alterations appeared particularly after bleeding. In the test-group animals evasion showed a decrease compared with the untreated control animals, but there was no evidence of a relation to the timing of the bleedings.