Publikationsdatenbank

Leukozyten-Agglomerationstest zur Feststellung mikrobieller Belastung (1990)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Juhr, N C

Stuckenberg, R

Quelle

Zeitschrift für Versuchstierkunde; 33(5) — S. 221–227

ISSN: 0044-3697

Verweise

Pubmed: 2148460

Kontakt

Institut für Tierschutz und Tierverhalten

Königsweg 67
Gebäude 21, 1. OG
14163 Berlin
+49 30 838 62901
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Transfer of laboratory animals from the breeder to the experimental unit includes in most cases a change of the microbial environment even under SPF-conditions. Many experimental treatments may also disturb the balance between host and microbial load and provoke infections. With the aim to detect such undesired effects in the course of the experiment the suitability of the leukergy test was investigated. SPF-rats, endotoxin-treated rats, and conventionalized germ-free rats were checked for leukocyte agglomeration, and the findings were compared with total leukocyte number, blood picture, endotoxin content in the blood and body temperature. A rise of leukergy from 10 to more than 20% was recorded in endotoxin-treated and conventionalized rats.