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    Modifikation der Teratogenese von Actinomycin-D und Cyclophosphamid durch eine Mycoplasma pulmonis-Infektion bei der Ratte (1990)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Juhr, N C
    Ratsch, H
    Quelle
    Zeitschrift für Versuchstierkunde; 33(6) — S. 265–270
    ISSN: 0044-3697
    Verweise
    Pubmed: 2150578
    Kontakt
    Institut für Tierschutz und Tierverhalten

    Königsweg 67
    Gebäude 21, 1. OG
    14163 Berlin
    +49 30 838 62901
    tierschutz@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    In the present investigation experiments have been made on the modification of the teratogenesis by a Mycoplasma pulmonis infection in rats. Substances with known teratogenic effects (Actinomycin D, Cyclophosphamide) were used. Groups of artificially infected pregnant rats were compared with pregnant rats from the SPF unit. The present study has shown that in the group of artificially infected animals no significant increase of the teratogenic effects by Actinomycin was found. In the Cyclophosphamide-treated groups more and more serious malformations have been observed in relation to dose and day of treatment.