Publikationsdatenbank

Modifikation der Teratogenese von Actinomycin-D und Cyclophosphamid durch eine Mycoplasma pulmonis-Infektion bei der Ratte (1990)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Juhr, N C

Ratsch, H

Quelle

Zeitschrift für Versuchstierkunde

Bandzählung: 33

Heftzählung: 6

Seiten: 265 – 270

ISSN: 0044-3697

Verweise

Pubmed: 2150578

Kontakt

Institut für Tierschutz, Tierverhalten und Versuchstierkunde

Königsweg 67
14163 Berlin
+49 30 838 61146
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

In the present investigation experiments have been made on the modification of the teratogenesis by a Mycoplasma pulmonis infection in rats. Substances with known teratogenic effects (Actinomycin D, Cyclophosphamide) were used. Groups of artificially infected pregnant rats were compared with pregnant rats from the SPF unit. The present study has shown that in the group of artificially infected animals no significant increase of the teratogenic effects by Actinomycin was found. In the Cyclophosphamide-treated groups more and more serious malformations have been observed in relation to dose and day of treatment.