Publikationsdatenbank

Stoffwechsel von 14C-markiertem Harnstoff bei konventionellen und bakterienfreien Meerschweinchen (1990)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Juhr, N C

Franke, J

Quelle

Zeitschrift für Versuchstierkunde

Bandzählung: 33

Heftzählung: 3

Seiten: 123 – 127

ISSN: 0044-3697

Verweise

Pubmed: 2144936

Kontakt

Institut für Tierschutz, Tierverhalten und Versuchstierkunde

Königsweg 67
14163 Berlin
+49 30 838 61146
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

This report deals with the utilization of 14C-labeled urea in antibiotically decontaminated, bacteria-free guinea pigs using intragastric resp. intraperitoneal administration route. With conventional animals 52% of the intragastrically administered 14C dose can be demonstrated in the exhaled air, 1.2% in organs and 41% in the urine. 1.8% were found in intestinal and faecal contents. In bacteria-free animals 29% of the activity appeared in the exhaled air, 52% in urine and 2% remain in the intestinal tract, feces and animal body. Intraperitoneal administration of 14C urea revealed 17% resp. 14% in the exhaled air, 72% resp. 66% in urine and 2% resp. 3% in intestinal tract, feces and animal body in conventional resp. bacteria-free guinea pigs.