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    Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis (2013)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Plickert, H D (WE 20)
    Bondzio, A (WE 3)
    Einspanier, R (WE 3)
    Tichy, A
    Brunnberg, L (WE 20)
    Quelle
    Research in Veterinary Science; 94(3) — S. 728–734
    ISSN: 0034-5288
    Sprache
    Englisch
    Verweise
    DOI: 10.1016/j.rvsc.2012.11.007
    Pubmed: 23261156
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    Abstract / Zusammenfassung

    To compare hyaluronic acid (HA) concentrations measured in synovial fluid (SF) of joints with different stages of canine secondary osteoarthritis (OA), clinical-orthopedic, radiographic, macroscopic intra-operative and SF findings of 49 joints were assessed. The sum of single findings was correlated to HA concentrations measured by a commercially available ELISA. Joints were categorized into three OA-groups: non-osteoarthritic, mildly osteoarthritic, and severely osteoarthritic. A significant negative correlation was found between severity of OA and HA concentrations (r=-0.696; P<0.001). Median values of HA concentrations decreased with increasing severity of the disease. Statistically significant differences in HA concentrations were observed between the OA-groups (P<0.001). Due to overlapping values between groups, it was concluded that synovial HA concentrations may only indicate a trend of osteoarthritic disease activity, but is not suitable for staging the disease.