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    SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women (2013)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Kolisek, Martin (WE 2)
    Galaviz-Hernández, C.
    Vázquez-Alaniz, F.
    Sponder, G. (WE 2)
    Javaid, S.
    Kurth, K.
    Nestler, A.
    Rodríguez-Moran, M.
    Verlohren, S.
    Guerrero-Romero, F.
    Aschenbach, Jörg R. (WE 2)
    Vormann, Jürgen
    Quelle
    Hypertension in pregnancy; 32(4) — S. 378–389
    ISSN: 1064-1955
    Sprache
    Englisch
    Verweise
    DOI: 10.3109/10641955.2013.810237
    Pubmed: 23844728
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    Institut für Veterinär-Physiologie

    Oertzenweg 19 b
    14163 Berlin
    Tel.+49 30 838 62600 Fax.+49 30 838-62610
    email:physiologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Objective: To examine expression profile of magnesium responsive genes (MRGs) in placentas of normoevolutive and preeclamptic women. Methods: The expression profiles of MRGs were determined in placentas of normoevolutive (N = 26) and preeclamptic (N = 25) women by RT-qPCR. Results: Among all tested MRGs (9) only SLC41A1 (encoding for Na+/Mg2+ exchanger) was significantly overexpressed in ∼54.2% of preeclamptic (n = 24) and in ∼9.5% of normoevolutive (n = 21) specimens. On average, SLC41A1 was overexpressed sixfold in the preeclamptic group. Presence of SLC41A1 in placentas was confirmed by Western blot analysis. Conclusion. SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas. This may indicate a direct contribution of changed Mg homeostasis in the development of preeclampsia.