Publication Database

SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women (2013)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Kolisek, Martin (WE 2)

Galaviz-Hernández, C.

Vázquez-Alaniz, F.

Sponder, G. (WE 2)

Javaid, S.

Kurth, K.

Nestler, A.

Rodríguez-Moran, M.

Verlohren, S.

Guerrero-Romero, F.

Aschenbach, Jörg R. (WE 2)

Vormann, Jürgen

Quelle

Hypertension in pregnancy

Bandzählung: 32

Heftzählung: 4

Seiten: 378 – 389

ISSN: 1064-1955

Sprache

Englisch

Verweise

DOI: 10.3109/10641955.2013.810237

Pubmed: 23844728

Kontakt

Institut für Veterinär-Physiologie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62600
physiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Objective: To examine expression profile of magnesium responsive genes (MRGs) in placentas of normoevolutive and preeclamptic women. Methods: The expression profiles of MRGs were determined in placentas of normoevolutive (N = 26) and preeclamptic (N = 25) women by RT-qPCR. Results: Among all tested MRGs (9) only SLC41A1 (encoding for Na+/Mg2+ exchanger) was significantly overexpressed in ∼54.2% of preeclamptic (n = 24) and in ∼9.5% of normoevolutive (n = 21) specimens. On average, SLC41A1 was overexpressed sixfold in the preeclamptic group. Presence of SLC41A1 in placentas was confirmed by Western blot analysis. Conclusion. SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas. This may indicate a direct contribution of changed Mg homeostasis in the development of preeclampsia.