Publikationsdatenbank

Microbial butyrate and its role for barrier function in the gastrointestinal tract (2012)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Plöger, S (WE 2)

Stumpff, Friederike (WE 2)

Penner, G. B.

Schulzke, J. D.

Gäbel, G.

Martens, H (WE 2)

Shen, Z.

Günzel, D.

Aschenbach, Jörg R. (WE 2)

Quelle

Annals of the New York Academy of Sciences; 1258 — S. 52–59

ISSN: 0077-8923

Sprache

Englisch

Verweise

DOI: 10.1111/j.1749-6632.2012.06553.x.

Pubmed: 22731715

Kontakt

Institut für Veterinär-Physiologie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62600
physiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Butyrate production in the large intestine and ruminant forestomach depends on bacterial butyryl-CoA/acetate-CoA transferase activity and is highest when fermentable fiber and nonstructural carbohydrates are balanced. Gastrointestinal epithelia seem to use butyrate and butyrate-induced endocrine signals to adapt proliferation, apoptosis, and differentiation to the growth of the bacterial community. Butyrate has a potential clinical application in the treatment of inflammatory bowel disease (IBD; ulcerative colitis). Via inhibited release of tumor necrosis factor α and interleukin 13 and inhibition of histone deacetylase, butyrate may contribute to the restoration of the tight junction barrier in IBD by affecting the expression of claudin-2, occludin, cingulin, and zonula occludens poteins (ZO-1, ZO-2). Further evaluation of the molecular events that link butyrate to an improved tight junction structure will allow for the elucidation of the cofactors affecting the reliability of butyrate as a clinical treatment tool.