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    Magnesium supplementation to prevent high blood pressure in pregnancy:
    a randomised placebo control trial (2013)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Bullarbo, Maria
    Ödman, Natalia
    Nestler, Axel
    Nielsen, Thorkild
    Kolisek, Martin (WE 2)
    Vormann, Jürgen
    Rylander, Ragnar
    Quelle
    Archives of gynecology and obstetrics; 288(6) — S. 1269–1274
    ISSN: 0932-0067
    Sprache
    Englisch
    Verweise
    DOI: 10.1007/s00404-013-2900-2
    Pubmed: 23715924
    Kontakt
    Institut für Veterinär-Physiologie

    Oertzenweg 19 b
    14163 Berlin
    Tel.+49 30 838 62600 Fax.+49 30 838-62610
    email:physiologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    PURPOSE:

    To assess if hypertension during the last part of pregnancy could be prevented by magnesium supplementation.
    METHODS:

    Pregnant primagravida women from a local antenatal care unit were given an oral supply of 300 mg magnesium as citrate or placebo from pregnancy week 25 in a randomised double-blind setup. Blood pressure was recorded during pregnancy as well as pregnancy outcome.
    RESULTS:

    In the magnesium-supplemented group, the average diastolic blood pressure at week 37 was significantly lower than in the placebo group (72/1.4 mean/SEM vs 77/1.4, p = 0.031). The number of women with an increase in diastolic blood pressure of ≥15 mmHg was significantly lower in the magnesium group compared with the women who received placebo (p = 0.011). There was an inverse relation between the urinary excretion of magnesium during pregnancy and the diastolic blood pressure (p = 0.005).
    CONCLUSIONS:

    Magnesium supplementation prevented an increase in diastolic blood pressure during the last weeks of pregnancy. The relation between diastolic blood pressure and urinary excretion of magnesium suggests that magnesium is involved in the regulation of blood pressure and that the increase in diastolic blood pressure in pregnancy could be due to a lack of magnesium.