Fachbereich Veterinärmedizin



    Epidemiological study of fowl glioma-inducing virus in chickens in Asia and Germany (2012)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Ochi, Akihiro
    Ochiai, Kenji
    Kobara, Akiko
    Nakamura, Sayuri
    Hatai, Hitoshi
    Handharyani, Ekowati
    Tiemann, Inga
    Tanaka, Ignacia B
    Toyoda, Takeshi
    Abe, Asumi
    Seok, Seung-Hyeok
    Sunden, Yuji
    Torralba, Nedeña C
    Park, Jae-Hak
    Hafez, Hafez Mohamed (WE 15)
    Umemura, Takashi
    Avian pathology : journal of the W.V.P.A; 41(3) — S. 299–309
    ISSN: 0307-9457
    DOI: 10.1080/03079457.2012.684373
    Pubmed: 22702458
    Institut für Geflügelkrankheiten

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    14163 Berlin
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    Abstract / Zusammenfassung

    Fowl glioma-inducing virus (FGV), which belongs to avian leukosis virus (ALV) subgroup A, induces fowl glioma. This disease is characterized by multiple nodular gliomatous growths of astrocytes and has been previously reported in Europe, South Africa, Australia, the United States and Japan. FGV and FGV variants have spread to ornamental Japanese fowl, including Japanese bantams (Gallus gallus domesticus), in Japan. However, it is unclear how and where FGV emerged and whether FGV is related to the past fowl glioma in European countries. In this study, the prevalence of FGV in European, Asian and Japanese native chickens was examined. FGV could not be isolated from any chickens in Germany and Asian countries other than Japan. Eighty (26%) out of 307 chickens reared in Japan were positive by FGV-screening nested polymerase chain reaction and 11 FGV variants with an FGV-specific sequence in their 3' untranslated region were isolated. In addition, four other ALVs lacking the FGV-specific sequence were isolated from Japanese bantams with fowl glioma and/or cerebellar hypoplasia. These isolates were considered to be distinct recombinant viruses between FGV variants and endogenous/exogenous avian retroviruses. These results suggest that the variants as well as distinct recombinant ALVs are prevalent among Japanese native chickens in Japan and that FGV may have emerged by recombination among avian retroviruses in the chickens of this country.