Fachbereich Veterinärmedizin



    Elimination half-life of intravenously administered equine cardiac troponin I in healthy ponies (2013)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Kraus, M S
    Kaufer, B B (WE 5)
    Damiani, A (WE 5)
    Osterrieder, N (WE 5)
    Rishniw, M
    Schwark, W
    Gelzer, A R
    Divers, T J
    Equine veterinary journal; 45(1) — S. 56–59
    ISSN: 2042-3306
    DOI: 10.1111/j.2042-3306.2012.00554.x
    Pubmed: 22432543
    Institut für Virologie

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14163 Berlin
    Tel. +49 30 838 51833 Fax. +49 30 838 451847

    Abstract / Zusammenfassung

    To date, no information is available on the true biological elimination half-life (T(1/2) ) of cardiac troponin I (cTnI) in the equine species. Such data are required to better evaluate the optimal time to acquire the cTnI sample following acute myocardial injury.

    To determine the T(1/2) of equine cTnI.

    Four healthy ponies received i.v. injections of recombinant equine cTnI. Plasma cTnI concentrations were measured with a point-of-care cTnI analyser at multiple time points after injection. Standard pharmacokinetic analysis was performed to establish the T(1/2) of cTnI.

    The average T(1/2) of cTnI was determined to be 0.47 h using a single rate elimination model.

    The elimination of recombinant equine cTnI following i.v. administration is very rapid. Establishing the T(1/2 ) of troponin provides critical information in understanding the clinical application of this cardiac biomarker in equine practice.