Publikationsdatenbank

Elimination half-life of intravenously administered equine cardiac troponin I in healthy ponies (2013)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Kraus, M S

Kaufer, B B (WE 5)

Damiani, A (WE 5)

Osterrieder, N (WE 5)

Rishniw, M

Schwark, W

Gelzer, A R

Divers, T J

Quelle

Equine veterinary journal : official journal of the British Equine Veterinary Association

Bandzählung: 45

Heftzählung: 1

Seiten: 56 – 59

ISSN: 0425-1644

Sprache

Englisch

Verweise

DOI: 10.1111/j.2042-3306.2012.00554.x

Pubmed: 22432543

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

To date, no information is available on the true biological elimination half-life (T(1/2) ) of cardiac troponin I (cTnI) in the equine species. Such data are required to better evaluate the optimal time to acquire the cTnI sample following acute myocardial injury.

To determine the T(1/2) of equine cTnI.

Four healthy ponies received i.v. injections of recombinant equine cTnI. Plasma cTnI concentrations were measured with a point-of-care cTnI analyser at multiple time points after injection. Standard pharmacokinetic analysis was performed to establish the T(1/2) of cTnI.

The average T(1/2) of cTnI was determined to be 0.47 h using a single rate elimination model.

The elimination of recombinant equine cTnI following i.v. administration is very rapid. Establishing the T(1/2 ) of troponin provides critical information in understanding the clinical application of this cardiac biomarker in equine practice.