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    Anthelmintic cyclcooctadepsipeptides:
    complex in structure and mode of action (2012)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Krücken, Jürgen (WE 13)
    Harder, Achim
    Jeschke, Peter
    Holden-Dye, Lindy
    O'Connor, Vincent
    Welz, Claudia
    von Samson-Himmelstjerna, Georg (WE 13)
    Quelle
    Trends in parasitology; 28(9) — S. 385–394
    ISSN: 1471-4922
    Sprache
    Englisch
    Verweise
    DOI: 10.1016/j.pt.2012.06.005
    Pubmed: 22858281
    Kontakt
    Institut für Parasitologie und Tropenveterinärmedizin

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35, 22, 23
    14163 Berlin
    Tel.+49 30 838 62310 Fax.+49 30 838 62323
    email:parasitologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    The broad-spectrum anthelmintic cyclooctadepsipeptide PF1022A is a fungal metabolite from Rosellinia sp. PF1022, which is a Mycelia sterilia found on the leaves of Camellia japonica. A broad range of structurally related cyclooctadepsipeptides has been characterized and tested for anthelmintic activities. These metabolites have been used as starting points to generate semisynthetic derivatives with varying nematocidal capacity. Predominant among these compounds is emodepside, which exhibits a broad nematocidal potential against gastrointestinal and extraintestinal parasites. Here we review the chemical biology and mode of action of cyclooctadepsides with particular attention to PF1022A and emodepside. We illustrate how they target nematode neuromuscular function, opening up new avenues for antiparasitic treatments with potential capability for important selective toxicity.