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    Intussusceptive angiogenesis:
    a biologically relevant form of angiogenesis (2012)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    De Spiegelaere, Ward
    Casteleyn, Christophe
    Van den Broeck, Wim
    Plendl, Johanna (WE 1)
    Bahramsoltani, Mahtab
    Simoens, Paul
    Djonov, Valentin
    Cornillie, Pieter
    Quelle
    Journal of vascular research : official journal of the European Society of Microcirculation; 49(5) — S. 390–404
    ISSN: 1018-1172
    Sprache
    Englisch
    Verweise
    DOI: 10.1159/000338278
    Pubmed: 22739226
    Kontakt
    Institut für Veterinär-Anatomie

    Koserstr. 20
    14195 Berlin
    Tel.+49 30 838 53555 Fax.+49 30 838-53480
    email:anatomie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Angiogenesis, i.e. the development and growth of blood vessels, is a major topic of research as it plays an important role in normal development and in various pathologies. Recent evidence revealed the existence of different mechanisms of blood vessel growth, including sprouting and intussusceptive angiogenesis, vascular mimicry, and blood vessel cooption. The latter two have only been observed in tumor growth, but sprouting and intussusceptive angiogenesis also occur in healthy, physiologically growing tissues. Despite this variety of angiogenic mechanisms, most of the current research is focused on the mechanism of sprouting angiogenesis because this mechanism was first described and because most existing experimental models are related to sprouting angiogenesis. Consequently, the mechanism of intussusceptive angiogenesis is often overlooked in angiogenesis research. Here, the mechanism of intussusceptive angiogenesis is reviewed and the current techniques and models for investigating intussusceptive angiogenesis are summarized. In addition, other mechanisms of vascular growth are briefly reviewed.