Publikationsdatenbank

Intussusceptive angiogenesis:
a biologically relevant form of angiogenesis (2012)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

De Spiegelaere, Ward

Casteleyn, Christophe

Van den Broeck, Wim

Plendl, Johanna (WE 1)

Bahramsoltani, Mahtab

Simoens, Paul

Djonov, Valentin

Cornillie, Pieter

Quelle

Journal of vascular research : official journal of the European Society of Microcirculation

Bandzählung: 49

Heftzählung: 5

Seiten: 390 – 404

ISSN: 1018-1172

Sprache

Englisch

Verweise

DOI: 10.1159/000338278

Pubmed: 22739226

Kontakt

Institut für Veterinär-Anatomie

Koserstr. 20
14195 Berlin
+49 30 838 75784
anatomie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Angiogenesis, i.e. the development and growth of blood vessels, is a major topic of research as it plays an important role in normal development and in various pathologies. Recent evidence revealed the existence of different mechanisms of blood vessel growth, including sprouting and intussusceptive angiogenesis, vascular mimicry, and blood vessel cooption. The latter two have only been observed in tumor growth, but sprouting and intussusceptive angiogenesis also occur in healthy, physiologically growing tissues. Despite this variety of angiogenic mechanisms, most of the current research is focused on the mechanism of sprouting angiogenesis because this mechanism was first described and because most existing experimental models are related to sprouting angiogenesis. Consequently, the mechanism of intussusceptive angiogenesis is often overlooked in angiogenesis research. Here, the mechanism of intussusceptive angiogenesis is reviewed and the current techniques and models for investigating intussusceptive angiogenesis are summarized. In addition, other mechanisms of vascular growth are briefly reviewed.