Gebäude 35, 22, 23
Tel.+49 30 838 62310 Fax.+49 30 838 62323
Water, methanol and dichlormethane extracts prepared from various parts of 40 medicinal plant species from Mali were investigated for their trypanocidal activity against Trypanosoma brucei brucei. Of a total of 165 extracts tested in vitro in the Low Inoculation Long Incubation Test (LILIT), 24 extracts showed a high trypanocidal activity. Using the Long term Viability Assay (LtVA) for corroboration of the results of the 24 extracts, it was found that 15 samples had minimum inhibitory concentration (MIC) values > 100 µg/ml, 8 MIC values of 100 µg/ml and one MIC values of 50 to 100 µg/ml. So far, 4 extracts with MIC values 100 µg/ml were tested for antitrypanosomal activity in mice, experimentally infected with T. brucei brucei. Only the aqueous extracts of the leaves of Terminalia avicennioides Guill. & Perr. (Combretaceae) and of the stem bark of Ceiba pentandra (L.) Gaertn. (Bombacaceae) were able to reduce the parasitaemia in animals treated at the dose of 100 mg/kg b.w. (intraperitoneally, 2 times daily for 3 days.) and of 150 mg/kg b.w. (per os, 2 times daily for 3 days), respectively. The reduction of parasitaemia was, however, statistically significant (p = 0,002) only in case of treatment with T. avicennioides.