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    Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa in mice and the drug incubation infectivity test (2006)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Knoppe, T. N.
    Bauer, B.
    McDermott, J. J.
    Peregrine, A. S.
    Mehlitz, D.
    Clausen, P. H.
    Quelle
    Acta tropica; 97(1) — S. 108–116
    ISSN: 0001-706x
    Sprache
    Englisch
    Verweise
    Pubmed: 16256933
    Kontakt
    Institut für Parasitologie und Tropenveterinärmedizin

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35, 22, 23
    14163 Berlin
    +49 30 838 62310
    parasitologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kénédougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation infectivity test (DIIT). All field stocks from Kénédougou were resistant to 1.0 mg/kg bw isometamidium in the SMT. Fourteen stocks (87.5%) also proved to be refractory to 10 mg/kg bw. Testing with the DIIT confirmed the results of the SMT. By comparison to reference clones, all the Kénédougou populations expressed high levels of resistance to isometamidium.