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    In vitro and in vivo trypanocidal effect of lipophilic extracts of medicinal plants from Mali and Burkina Faso (2008)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Aderbauer, B.
    Clausen, P-H
    Kershaw, O.
    Melzig, M. F.
    Quelle
    Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs; 119(2) — S. 225–231
    ISSN: 0378-8741
    Sprache
    Englisch
    Verweise
    DOI: 10.1016/j.jep.2008.06.024
    Pubmed: 18638537
    Kontakt
    Institut für Parasitologie und Tropenveterinärmedizin

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35, 22, 23
    14163 Berlin
    +49 30 838 62310
    parasitologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    AIM OF THE STUDY:

    To determine the in vitro and in vivo antitrypanosomal activity of extracts of traditionally used plants.
    MATERIALS AND METHODS:

    47 dichloromethane extracts were tested in vitro in the Long-term Viability Assay (LtVA) on Trypanosoma brucei brucei. The most active ones were also tested in vivo using a standardised mouse test.
    RESULTS:

    13 extracts (28%) were active in vitro with MIC-values < or = 100 microg/ml, 6 extracts showed MIC-values < or = 50 microg/ml. The root extract of Securidaca longepedunculata Fresen. (Polygalaceae) and the leaf extract of Guiera senegalensis J. F. Gmel. (Combretaceae) were able to reduce parasitaemia in mice, experimentally infected with Trypanosoma brucei brucei by 48 and 42% at the dose of 150 mg/kg b.w. intraperitoneally, two times daily for 3 days. The extract of Acacia nilotica Delile (Mimosaceae) stem bark showed immunosuppressive effect in vivo.
    CONCLUSION:

    The results confirm an effect of the ethnobotanically used plants. Further investigation is needed to optimize the effectiveness of the extracts.