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    Characterization of organic dust exposure by using a human whole blood assay (2002)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Zucker, B. A.
    Linsel, G.
    Fennrich, S.
    Kindinger, I.
    Hartung, T.
    Müller, W.
    Quelle
    Landbauforschung Völkenrode = FAL agricultural research / FAL, Bundesforschungsanstalt für Landwirtschaft; 235 — S. 125–128
    ISSN: 0458-6859
    Sprache
    Englisch
    Kontakt
    Institut für Tier- und Umwelthygiene

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14169 Berlin
    Tel.+49 30 8385 1845 Fax.+49 30 83845 1863
    email:tierhygiene@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Exposure to organic dusts or bioaerosols is associated with a variety of acute and chronic
    respiratory symptoms. In seeking to control organic dust-induced diseases it is necessary to identify and quantify the toxic agents in the dust.
    Here we describe an in vitro assay – a human whole blood assay- that can be used to estimate the inflammatory potency of organic dust samples. With the whole blood assay the inflammation reaction that bioaerosols cause in the respiratory tract is exactly characterized. That assay is able to detect a broad spectrum of macrophage activating substances and not only endotoxins as the limulus assay.