Publikationsdatenbank

Characterization of organic dust exposure by using a human whole blood assay (2002)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Zucker, B. A.

Linsel, G.

Fennrich, S.

Kindinger, I.

Hartung, T.

Müller, W.

Quelle

Landbauforschung Völkenrode = FAL agricultural research / FAL, Bundesforschungsanstalt für Landwirtschaft

Bandzählung: 235

Seiten: 125 – 128

ISSN: 0458-6859

Sprache

Englisch

Kontakt

Institut für Tier- und Umwelthygiene

Robert-von-Ostertag-Str. 7-13
14169 Berlin
+49 30 838 51845
tierhygiene@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Exposure to organic dusts or bioaerosols is associated with a variety of acute and chronic
respiratory symptoms. In seeking to control organic dust-induced diseases it is necessary to identify and quantify the toxic agents in the dust.
Here we describe an in vitro assay – a human whole blood assay- that can be used to estimate the inflammatory potency of organic dust samples. With the whole blood assay the inflammation reaction that bioaerosols cause in the respiratory tract is exactly characterized. That assay is able to detect a broad spectrum of macrophage activating substances and not only endotoxins as the limulus assay.