Publikationsdatenbank

TorsinA, the gene linked to early-onset dystonia, is upregulated by the dopaminergic toxin MPTP in mice (2004)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Kuner, Rohini

Teismann, Peter

Trutzel, Annette

Naim, Jomana

Richter, Angelika

Schmidt, Nicole

Bach, Alfred

Ferger, Boris

Schneider, Armin

Quelle

Neuroscience Letters; 355(1/2) — S. 126–130

ISSN: 0304-3940

Sprache

Englisch

Verweise

Pubmed: 14729251

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
Tel.+49 30 838 53221 Fax.+49 30 838 53112
email:pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Early-onset torsion dystonias are caused by a mutation in TorsinA, a protein widely expressed in the nervous system. Here we report the cloning of the murine TorsinA cDNA and a mRNA in situ hybridization analysis of the expression patterns of TorsinA over developmental periods relevant to the etiology of early-onset dystonias. Several studies have demonstrated a functional involvement of the nigrostriatal dopaminergic system in pathological mechanisms underlying dystonia. In this study, we show that the expression of TorsinA is significantly increased in the brain within hours of treatment with the dopaminergic toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice, suggesting that the TorsinA gene is regulated by cellular stress. These results provide insights into the pathophysiology of early-onset dystonia and strengthen links between the dopaminergic system and dystonia.