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    High-frequency stimulation of the entopeduncular nucleus improves dystonia in dtsz hamsters (2004)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Harnack, Daniel
    Hamann, Melanie
    Meissner, Wassilios
    Morgenstern, Rudolf
    Kupsch, Andreas
    Richter, Angelika
    Quelle
    Neuroreport : an international journal for the rapid communication of research in neuroscience; 15(9) — S. 1391–1393
    ISSN: 0959-4965
    Sprache
    Englisch
    Verweise
    Pubmed: 15194859
    Kontakt
    Institut für Pharmakologie und Toxikologie

    Koserstr. 20
    14195 Berlin
    +49 30 838 53221
    pharmakologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    High-frequency stimulation (HFS) of the internal pallidum (GPi) has been reported to improve generalized dystonia in patients. Currently, dystonia is thought to be associated with disturbed neuronal activity of GPi neurons. Similar findings have been observed in the dtsz hamster, a model of idiopathic paroxysmal non-kinesiogenic dystonia. For this reason, we investigated the effect of bilateral HFS of the entopeduncular nucleus (EPN, rodent homologue of GPi) on the severity of dystonia. Bilateral EPN-HFS resulted in a reversible decrease of dystonia severity up to 50% when compared to both pre- and post-HFS scores, and controls. Our results underline the pathophysiological role of the EPN in the dtsz hamster and suggest the suitability of this model to further investigate mechanisms of HFS in dystonia.