Publikationsdatenbank

Effects of rubral microinjections of muscimol and bicuculline in a genetic animal model of paroxysmal dystonia (2004)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Hamann, Melanie

Richter, Angelika

Quelle

Brain research

Bandzählung: 1008

Heftzählung: 1

Seiten: 126 – 130

ISSN: 0006-8993

Sprache

Englisch

Verweise

Pubmed: 15081391

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Previous studies suggested that GABAergic dysfunctions within the red nucleus are involved in stress-inducible paroxysmal dystonia of the dt(sz) mutant hamster. In the present study, rubral microinjections of the GABAA receptor agonist muscimol exerted only moderate antidystonic effects and the antagonist bicuculline failed to show significant effects on the severity of dystonia. These data indicate that disturbed rubral GABAergic inhibition is not important for the manifestation of dystonia in the dt(sz) mutant.