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    Kreuzresistenzen gegenüber antimikro- biellen Wirkstoffen in der Veterinär- medizin: Molekulare Grundlagen und praktische Bedeutung für die Empfind- lichkeitsprüfung:
    Cross-resistance between antimicrobial agents used in veterinary medicine: molecular background and practical consequences for susceptibility testing (2005)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Werckenthin, Christiane
    Böttner, Alexander
    Hafez, H Mohamed
    Hartmann, Katrin
    Kaske, Martin
    Kehrenberg, Corinna
    Kietzmann, Manfred
    Klarmann, Dieter
    Klein, Günter
    Krabisch, Peter
    Kühn, Tilman
    Luhofer, Gabriele
    Richter, Angelika
    Schulz, Bianka
    Schwarz, Stefan
    Sigge, Claudia
    Traeder, Wolfgang
    Waldmann, Karl-Heinz
    Wallmann, Jürgen
    Quelle
    Berliner und Münchener tierärztliche Wochenschrift; 118(11-12) — S. 471–480
    ISSN: 0005-9366
    Sprache
    Englisch
    Verweise
    Pubmed: 16318271
    Kontakt
    Institut für Geflügelkrankheiten

    Königsweg 63
    14163 Berlin
    Tel.+49 30 838 62676 Fax.+49 30 838 62690
    email:gefluegelkrankheiten@vetmed.fu-berlin

    Abstract / Zusammenfassung

    Phenotypic resistance of veterinary pathogens to more than one antimicrobial agent (multi-resistance) may be caused by intrinsic resistance to the antimicrobial agents, acquired cross-resistance, or acquired co-resistance. Known cross-resistances allow to select so-called "representative substances" which are tested and the results of which can also be regarded as being valid for other members of the same class of antimicrobial agents. In general, a limitation in the number of antimicrobial agents to be tested in routine diagnostics is necessary because of capacity and cost efficiency. This is of particular relevance when the broth microdilution method - recommended as the method of choice - with 96-well microtiter plates is used. The knowledge about the relationship between different resistance phenotypes and the corresponding resistance mechanisms is of major value for both, the laboratory personnel and the veterinary practitioner. This review explains how "representative substances" for the most relevant classes of antimicrobial agents used in veterinary medicine are chosen on the basis of known cross-resistances.